Hematological Analysis in Thai Samples With Deletional and Nondeletional HbH Diseases
نویسندگان
چکیده
منابع مشابه
Application of Monoclonal and Polyclonal Antibodies to Hb Bart’s for the Detection of Thalassemias
Using a mouse monoclonal antibody (mAb) (“2D4”) with high specific reactivity to Hb Bart’s and a rabbit polyclonal antibody (“RPB”) with high reactivity to Hb Bart’s but low reactivity to HbF, an ELISA assay was developed for the quantification of Hb Bart’s in hemolysates of peripheral blood. In the preliminary study, hemoglobin solutions containing 4,000 μg/mL of hemoglobin were analyzed for t...
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We describe 27 cases of mild-to-severe α-thalassemia (α-thal) syndrome caused by interaction of Hb Adana [α59(E8)Gly→Asp, GGC>GAC (α2)] with deletional and nondeletional α(+)-thal mutations in Indonesian patients. Hematological profiles and clinical manifestations of all patients were assessed by routine procedures. The genotypes were generated by a multiplex-polymerase chain reaction (m-PCR), ...
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15 صفحه اولMolecular Basis of α-Thalassemia in Iran
Alpha-thalassemia (α-thal) is probably the most prevalent monogenic condition in the world. Deletions are the most common types of mutations in α-thal, followed by point mutations and small insertion/deletion. In the context of national screening program for prevention of thalassemia and hemoglobinopathies in Iran, α-thal carriers have come to more attention. Therefore, the fr...
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ژورنال
عنوان ژورنال: Laboratory Medicine
سال: 2018
ISSN: 0007-5027,1943-7730
DOI: 10.1093/labmed/lmx068